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Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?

22 Apr 2021

Abstract excerpt

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength. Its wide-ranging biological effects may include the reversal of senescence in clinical applications, as well as the...

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PMID: 33886503
DOI: 10.18632/aging.202881

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