Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.

International journal of molecular sciences - 1 Mar 2017

Dayal Shubham, Zhou Jun, Manivannan Praveen, Siddiqui Mohammad Adnan, Ahmad Omaima Farid, Clark Matthew, Awadia Sahezeel, Garcia-Mata Rafael, Shemshedini Lirim, Malathi Krishnamurthy

Abstract excerpt

The interferon antiviral pathways and prostate cancer genetics converge on a regulated endoribonuclease, RNase L. Positional cloning and linkage studies mapped Hereditary Prostate Cancer 1 (HPC1) to RNASEL. To date, there is no correlation of viral infections with prostate cancer, suggesting that RNase L may play additional roles in tumor suppression. Here, we demonstrate a role of RNase L as a suppressor of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoribonucleases

Share to Enzyme Activation

Share to Matrix Metalloproteinases

Share to Prostatic Neoplasms

Share to Protein Stability

Share to Receptors, Androgen

Source

Open in PubMed Open full text

Identifiers

PMID: 28257035
DOI: 10.3390/ijms18030529
PMCID: PMC5372545

Genes

RNASEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.PMID 28257035Read ↗

Involvement of the RNAse L gene in prostate cancer.Semantic proximity Read ↗

Mapping of the Human <i>RNASEL</i> Promoter and Expression in Cancer and Normal CellsSemantic proximity Read ↗

Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways.Semantic proximity Read ↗

Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study.Semantic proximity Read ↗

ELAC2 is a functional prostate cancer risk allele.Semantic proximity Read ↗

Genetic variation in RNASEL associated with prostate cancer risk and progression.Semantic proximity Read ↗

Autocrine Proteinase Activated Receptor (PAR) mediated signaling in prostate cancer cellsSemantic proximity Read ↗

Positive selection on the gene RNASEL: correlation between patterns of evolution and function.Semantic proximity Read ↗

Analysis of the RNASEL/HPC1, and macrophage scavenger receptor 1 in Asian-Indian advanced prostate cancer.Semantic proximity Read ↗

A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.Semantic proximity Read ↗

RNase-L Control of Cellular mRNAs: Roles in Biologic Functions and Mechanisms of Substrate TargetingSemantic proximity Read ↗

Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.