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Article

Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways.

The Journal of biological chemistry - 25 Nov 2005

Bettoun David J, Scafonas Angela, Rutledge Su Jane, Hodor Paul, Chen Oliver, Gambone Carlo, Vogel Robert, McElwee-Witmer Sheila, Bai Chang, Freedman Leonard, Schmidt Azriel

Abstract excerpt

Signaling by androgens and interferons (IFN) plays an important role in prostate cancer initiation and progression. Using microarray analysis, we describe here a functional cross-talk between dihydrotestosterone and interferon signaling. Glutathione S-transferase pull-down and co-immunoprecipitation experiments reveal that the androgen receptor and the interferon-activated RNase L interact with each other in a...

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Identifiers

PMID: 16166078
DOI: 10.1074/jbc.C500324200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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