Article
The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel.
Scientific reports - 3 Mar 2017
Pham Thieng, Perry Jacob L, Dosey Timothy L, Delcour Anne H, Hyser Joseph M
Abstract excerpt
Viroporins are small virus-encoded ion channel proteins. Most viroporins are monovalent selective cation channels, with few showing the ability to conduct divalent cations, like calcium (Ca2+). Nevertheless, some viroporins are known to disrupt host cell Ca2+ homeostasis, which is critical for virus replication and pathogenesis. Rotavirus nonstructural protein 4 (NSP4) is an endoplasmic reticulum transmembrane...
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