HLA specificities are associated with prognosis in IGHV-mutated CLL-like high-count monoclonal B cell lymphocytosis.

doi:10.1371/journal.pone.0172978

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Article

HLA specificities are associated with prognosis in IGHV-mutated CLL-like high-count monoclonal B cell lymphocytosis.

PloS one - 1 Jan 2017

García-Álvarez María, Alcoceba Miguel, López-Parra Miriam, Puig Noemí, Antón Alicia, Balanzategui Ana, Prieto-Conde Isabel, Jiménez Cristina, Sarasquete María E, Chillón M Carmen, Gutiérrez María Laura, Corral Rocío, Alonso José María, Queizán José Antonio, Vidán Julia, Pardal Emilia, Peñarrubia María Jesús, Bastida José M, García-Sanz Ramón, Marín Luis, González Marcos

Abstract excerpt

INTRODUCTION: Molecular alterations leading progression of asymptomatic CLL-like high-count monoclonal B lymphocytosis (hiMBL) to chronic lymphocytic leukemia (CLL) remain poorly understood. Recently, genome-wide association studies have found 6p21.3, where the human leukocyte antigen (HLA) system is coded, to be a susceptibility risk region for CLL. Previous studies have produced discrepant results regarding the...

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PMID: 28249016
DOI: 10.1371/journal.pone.0172978
PMCID: PMC5332061

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