Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis.

doi:10.1182/bloodadvances.2023012242

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Article

Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis.

Blood advances - 14 May 2024

Kleinstern Geffen, Boddicker Nicholas J, O'Brien Daniel R, Allmer Cristine, Rabe Kari G, Norman Aaron D, Griffin Rosalie, Yan Huihuang, Ma Tao, Call Timothy G, Bruins Laura, Brown Sochilt, Bonolo de Campos Cecilia, Hanson Curtis A, Leis Jose F, Ding Wei, Vachon Celine M, Kay Neil E, Oakes Christopher C, Parker Alexander S, Brander Danielle M, Weinberg J Brice, Furman Richard R, Shanafelt Tait D, Cerhan James R, Parikh Sameer A, Braggio Esteban, Slager Susan L

Abstract excerpt

ABSTRACT: High-count monoclonal B-cell lymphocytosis (HCMBL) is a precursor condition to chronic lymphocytic leukemia (CLL). We have shown that among individuals with HCMBL, the CLL-International Prognostic Index (CLL-IPI) is prognostic for time-to-first therapy (TTFT). Little is known about the prognostic impact of somatically mutated genes among individuals with HCMBL. We sequenced DNA from 371 individuals with...

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PMID: 38359367
DOI: 10.1182/bloodadvances.2023012242
PMCID: PMC11059316

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