Article
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues.
Journal of cellular biochemistry - 1 Jun 2007
Norris Russell A, Damon Brook, Mironov Vladimir, Kasyanov Vladimir, Ramamurthi Anand, Moreno-Rodriguez Ricardo, Trusk Thomas, Potts Jay D, Goodwin Richard L, Davis Jeff, Hoffman Stanley, Wen Xuejun, Sugi Yukiko, Kern Christine B, Mjaatvedt Corey H, Turner Debi K, Oka Toru, Conway Simon J, Molkentin Jeffery D, Forgacs Gabor, Markwald Roger R
Abstract excerpt
Periostin is predominantly expressed in collagen-rich fibrous connective tissues that are subjected to constant mechanical stresses including: heart valves, tendons, perichondrium, cornea, and the periodontal ligament (PDL). Based on these data we hypothesize that periostin can regulate collagen I fibrillogenesis and thereby affect the biomechanical properties of connective tissues. Immunoprecipitation and...
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