Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.

doi:10.1371/journal.pone.0172880

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Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.

PloS one - 1 Jan 2017

Parra Esteban J, Mazurek Andrew, Gignoux Christopher R, Sockell Alexandra, Agostino Michael, Morris Andrew P, Petty Lauren E, Hanis Craig L, Cox Nancy J, Valladares-Salgado Adan, Below Jennifer E, Cruz Miguel

Abstract excerpt

We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing...

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PMID: 28245265
DOI: 10.1371/journal.pone.0172880
PMCID: PMC5330487

Genes

APOA5
BUD13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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