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Article

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

3 Feb 2014

Abstract excerpt

Lead inhibitors that target the function of the hepatitis C virus (HCV) nonstructural 5A (NS5A) protein have been identified by phenotypic screening campaigns using HCV subgenomic replicons. The demonstration of antiviral activity in HCV-infected subjects by the HCV NS5A replication complex inhibitor (RCI) daclatasvir (1) spawned considerable interest in this mechanistic approach. In this Perspective, we...

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PMID: 24621191
DOI: 10.1021/jm401793m

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