Article
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
Cell genomics - 8 May 2024
Wang Yahui, Liu Xinyi, Zuo Xianbo, Wang Cuiling, Zhang Zheng, Zhang Haitao, Zeng Tao, Chen Shunqi, Liu Mengyu, Chen Hongxia, Song Qingfeng, Li Qi, Yang Chenning, Le Yi, Xing Jinliang, Zhang Hongxin, An Jiaze, Jia Weihua, Kang Longli, Zhang Hongxing, Xie Hui, Ye Jiazhou, Wu Tianzhun, He Fuchu, Zhang Xuejun, Li Yuanfeng, Zhou Gangqiao
Abstract excerpt
To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 controls. We identified four HCC-associated genes, including NRDE2, RANBP17, RTEL1, and STEAP3. Using NRDE2 (index rs199890497 [p.N377I], p = 1.19 × 10-9) as an exemplary candidate, we demonstrated that it promotes homologous...
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