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Article

Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription

23 Jul 2021

Abstract excerpt

BACKGROUND AND AIMS: AT-rich interactive domain-containing protein 1A (ARID1A) is frequently mutated or deficient in hepatocellular carcinoma (HCC). However, the role of ARID1A in HCC remains unclear. Therefore, the biological role of ARID1A in HCC was evaluated and a potential mechanism was investigated. METHODS: was knocked out in the livers of mice using the CRISPR/Cas9 system delivered by hydrodynamic tail...

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PMID: 34447682
DOI: 10.14218/jcth.2021.00111

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