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Article

The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples.

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Apr 2017

Minică Camelia C, Genovese Giulio, Hultman Christina M, Pool René, Vink Jacqueline M, Neale Michael C, Dolan Conor V, Neale Benjamin M

Abstract excerpt

Sequence-based association studies are at a critical inflexion point with the increasing availability of exome-sequencing data. A popular test of association is the sequence kernel association test (SKAT). Weights are embedded within SKAT to reflect the hypothesized contribution of the variants to the trait variance. Because the true weights are generally unknown, and so are subject to misspecification, we...

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PMID: 28238293
DOI: 10.1017/thg.2017.7
PMCID: PMC5357183

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VARS2

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