Exploration of weighting schemes based on allele frequency and annotation for weighted burden association analysis of complex phenotypes.

Abstract excerpt

Weighted burden analysis can incorporate variants with different frequencies and annotations into a combined test for association between a gene and a phenotype. However there has not been a systematic exploration of which weighting schemes provide maximum power to detect association. Here we assess different weighting schemes using a number of genes for which exome-wide evidence of association with common...

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