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Article

C5aR contributes to the weak Th1 profile induced by an outbreak strain of Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2017

Sabio Y García Carmen Alejandra, Yokobori Noemí, Basile Juan Ignacio, Balboa Luciana, González Alejandra, López Beatriz, Ritacco Viviana, Barrera Silvia de la, Sasiain María Del Carmen

Abstract excerpt

C5a anaphylatoxin is a component of the complement system involved in the modulation of T-cell polarization. Herein we investigated whether C5a receptors, C5aR and C5L2, modulate the cytokine profiles induced by Mycobacterium tuberculosis (Mtb). We analyzed the impact of both receptors on T helper cell polarization induced by the multidrug resistant outbreak strain named M, which is a poor IFN-γ inducer compared...

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Identifiers

PMID: 28237029
DOI: 10.1016/j.tube.2016.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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