Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C1q and mannose-binding lectin binding and complement activation across genetically diverse Mycobacterium tuberculosis complex strains.

Journal of immunology (Baltimore, Md. : 1950) - 9 Feb 2026

Duque-Villegas Mario Alejandro, Götz Maximilian Peter, Rousseau Emilie, Homolka Susanne, Niemann Stefan, Garred Peter, Hölscher Christoph, Walter Kerstin, Rosbjerg Anne

Abstract excerpt

The Mycobacterium tuberculosis complex (MTBC), comprising species such as M. tuberculosis, M. africanum, and M. canettii, is the causative agent of tuberculosis (TB), one of the deadliest infectious diseases worldwide. MTBC strains exhibit genetic diversity that influences host-pathogen interactions, immune evasion, and disease outcomes. The complement system, a crucial component of innate immunity, plays a dual...

Topics

Join the communities discussing this publication.

Complement Activation
Complement C1q
Host-Pathogen Interactions
Immune Evasion
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mannose-Binding Lectin

Mycobacterium tuberculosis

Source

Identifiers

PMID: 41264261
DOI: 10.1093/jimmun/vkaf294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C1q and mannose-binding lectin binding and complement activation across genetically diverse Mycobacterium tuberculosis complex strains.PMID 41264261Read ↗

C1q in non-immune human serum has a non-redundant complement function towards clinical Mycobacterium tuberculosis complex strainsSemantic proximity Read ↗

Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.Semantic proximity Read ↗

Mycobacterium tuberculosis modifies cell wall carbohydrates during biofilm growth with a concomitant reduction in complement activationSemantic proximity Read ↗

C-type lectin receptors in tuberculosis: what we know.Semantic proximity Read ↗

Mannose-binding lectin deficiency and respiratory tract infection.Semantic proximity Read ↗

Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.Semantic proximity Read ↗

C5aR contributes to the weak Th1 profile induced by an outbreak strain of Mycobacterium tuberculosis.Semantic proximity Read ↗

Macrophage—Mycobacterium tuberculosis interactions: role of complement receptor 3Semantic proximity Read ↗

Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis.Semantic proximity Read ↗

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restrictionSemantic proximity Read ↗

<i>Mycobacterium tuberculosis</i> modifies cell wall carbohydrates during biofilm growth with a concomitant reduction in complement activationSemantic proximity Read ↗

The emerging role of complement lectin pathway in trypanosomatids: molecular bases in activation, genetic deficiencies, susceptibility to infection, and complement system-based therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.