Article

p21 <sup>CIP1/WAF1</sup> -mediated partial senescence supports steroidogenesis and therapy resistance in primary prostate cancer cultures

2026-01-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Progression of prostate cancer to castration-resistant disease is driven by early adaptive mechanisms that remain poorly defined. Increasing evidence suggests that senescence-associated programs and intratumoral steroidogenesis may contribute to therapeutic resistance, but their functional interplay in hormone-naïve disease is unclear. <h4>Methods</h4> Hormone-naïve primary...

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Literature Corpus work: 629e775b-b063-52ed-be28-5bb911c05655
DOI: 10.64898/2026.01.15.699666

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