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Article

Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.

The Journal of steroid biochemistry and molecular biology - 1 Jan 2017

Kawata Hirotoshi, Kamiakito Tomoko, Nakaya Takeo, Komatsubara Maiko, Komatsu Kenji, Morita Tatsuo, Nagao Yasumitsu, Tanaka Akira

Abstract excerpt

Endocrine resistance is a major problem in prostate cancer. Recent studies suggest that cellular plasticity plays a key role in therapy resistance. Yet little is known about the cellular changes of human prostate cancer after androgen deprivation therapy (ADT). In this study, we investigated cellular senescence, senescence-associated secretory phenotypes (SASPs), and anti-oxidant responses. Hormone ablation...

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PMID: 27329245
DOI: 10.1016/j.jsbmb.2016.06.007

Genes

MMP2
NQO1

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