Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

6 Feb 2017

Abstract excerpt

BACKGROUND: Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent patterns, prompting us to investigate whether epigenetic repression of microRNAs expression might disrupt senescence in prostate cancer (PCa) cells. METHODS: Differential methylation mapping in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28166834
DOI: 10.1186/s13045-017-0415-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancerPMID 28166834Read ↗

The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancerSemantic proximity Read ↗

A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97Semantic proximity Read ↗

N6-methyladenosine-modified circRPS6KC1 regulated cell senescence in prostate cancer via FOXM1/PCNA axisSemantic proximity Read ↗

Prediction of prognosis and immune response in prostate cancer by senescence-associated lncRNA signatureSemantic proximity Read ↗

lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axisSemantic proximity Read ↗

The identification of senescence-specific genes during the induction of senescence in prostate cancer cells.Semantic proximity Read ↗

Novel Pathways Associated with Bypassing Cellular Senescence in Human Prostate Epithelial CellsSemantic proximity Read ↗

miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells.Semantic proximity Read ↗

MicroRNA in prostate cancer: functional importance and potential as circulating biomarkersSemantic proximity Read ↗

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer.Semantic proximity Read ↗

MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescenceSemantic proximity Read ↗

Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.