Article
Targeted Next-Generation Sequencing for Human Leukocyte Antigen Typing in a Clinical Laboratory: Metrics of Relevance and Considerations for Its Successful Implementation.
Archives of pathology & laboratory medicine - 1 Jun 2017
Gandhi Manish J, Ferriola Deborah, Huang Yanping, Duke Jamie L, Monos Dimitri
Abstract excerpt
CONTEXT: - Numerous feasibility studies to type human leukocyte antigens (HLAs) by next-generation sequencing (NGS) have led to the development of vendor-supported kits for HLA typing by NGS. Some clinical laboratories have introduced HLA-NGS, and many are investigating the introduction. Standard...
Topics
- Alleles
- Exons
- Genotype
- Genotyping Techniques
- HLA Antigens
- High-Throughput Nucleotide Sequencing
- Histocompatibility Testing
- Humans
- Reproducibility of Results
- Sequence Analysis, DNA