Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

7 Oct 2011

Abstract excerpt

BACKGROUND: APP expression misregulation can cause genetic Alzheimer's disease (AD). Recent evidences support the hypothesis that polymorphisms located in microRNA (miRNA) target sites could influence the risk of developing neurodegenerative disorders such as Parkinson's disease (PD) and frontotemporal dementia. Recently, a number of single nucleotide polymorphisms (SNPs) located in the 3'UTR of APP have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to MicroRNA in disease regulation
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21982160
DOI: 10.1186/1750-1326-6-70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA functionPMID 21982160Read ↗

Relationship between single nucleotide polymorphisms in the 3′UTR of amyloid precursor protein and risk of Alzheimer’s disease and its mechanismSemantic proximity Read ↗

A complex crosstalk between polymorphic microRNA target sites and AD prognosis.Semantic proximity Read ↗

Human microRNA (miR-20b-5p) modulates Alzheimer’s disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer’s biomarkersSemantic proximity Read ↗

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.Semantic proximity Read ↗

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.Semantic proximity Read ↗

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.Semantic proximity Read ↗

MicroRNA Dysregulation in Alzheimer's DiseaseSemantic proximity Read ↗

Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3'-UTR variation.Semantic proximity Read ↗

Genome-wide identification of microRNA-related variants associated with risk of Alzheimer's disease.Semantic proximity Read ↗

Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease.Semantic proximity Read ↗

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s DiseaseSemantic proximity Read ↗

Functional characterization of amyloid beta precursor protein regulatory elements: rationale for the identification of genetic polymorphism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.