Article
[Molecular biology of beta A4 protein and Alzheimer disease].
Revue neurologique - 1 Jan 2000
Charnay Y, Vallet P G, Giannakopoulos P, Hof P R, Bouras C
Abstract excerpt
Senile plaques, neurofibrillary tangles and neuronal loss are the major histopathologic hallmarks of Alzheimer's disease. A prominent component of the senile plaques is a polypeptide (beta A4) of about 40 amino acids derived via proteolytic cleavage from a set of larger protein isoforms collectively referred to as the amyloid precursor protein (APP). The protein APP is a widely distributed transmembrane...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Cerebral Cortex
- Humans
- Molecular Sequence Data
- Mutation
- Protein Conformation