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Article

The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera.

Experimental hematology - 1 Jun 2017

Falchi Mario, Varricchio Lilian, Martelli Fabrizio, Marra Manuela, Picconi Orietta, Tafuri Agostino, Girelli Gabriella, Uversky Vladimir N, Migliaccio Anna Rita

Abstract excerpt

Calreticulin (CALR) is a Ca2+-binding protein that shuttles among cellular compartments with proteins bound to its N/P domains. The knowledge that activation of the human erythropoietin receptor induces Ca2+ fluxes prompted us to investigate the role of CALR in human erythropoiesis. As shown by Western blot analysis, erythroblasts generated in vitro from normal sources and JAK2V617F polycythemia vera (PV)...

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Source

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Identifiers

PMID: 28232234
DOI: 10.1016/j.exphem.2017.02.001
PMCID: PMC5779852

Genes

CALR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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