Article
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing.
Nature - 8 Jul 1999
Adachi-Yamada T, Fujimura-Kamada K, Nishida Y, Matsumoto K
Abstract excerpt
Distinct and evolutionarily conserved signal-transduction cascades mediate the survival or death of cells during development. The c-Jun amino-terminal kinases (JNKs) of the mitogen-activated protein kinase superfamily are involved in apoptotic signalling in various cultured cells. However, the role of the JNK pathway in development is less well understood. In Drosophila, Decapentaplegic (Dpp; a homologue of...
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