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Article

In vitro exploration of latent prothrombin mutants conveying antithrombin resistance.

Thrombosis research - 1 Nov 2017

Tamura Shogo, Murata-Kawakami Moe, Takagi Yuki, Suzuki Sachiko, Katsumi Akira, Takagi Akira, Kojima Tetsuhito

Abstract excerpt

INTRODUCTION: Antithrombin resistance (ATR) prothrombinemia is an inherited thrombophilic disorder caused by missense mutations in prothrombin gene (F2) at Arg596 of the sodium-binding region. Previously, prothrombin mutants Yukuhashi (Arg596Leu), Belgrade (Arg596Gln), and Padua 2 (Arg596Trp) were reported as ATR-prothrombins possessing a risk of familial venous thrombosis. To identify additional F2 mutations...

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Identifiers

PMID: 28961453
DOI: 10.1016/j.thromres.2017.09.020

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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