Article
Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2005
Sumby Paul, Barbian Kent D, Gardner Donald J, Whitney Adeline R, Welty Diane M, Long R Daniel, Bailey John R, Parnell Michael J, Hoe Nancy P, Adams Gerald G, Deleo Frank R, Musser James M
Abstract excerpt
Many pathogenic bacteria produce extracellular DNase, but the benefit of this enzymatic activity is not understood. For example, all strains of the human bacterial pathogen group A Streptococcus (GAS) produce at least one extracellular DNase, and most strains make several distinct enzymes. Despite six decades of study, it is not known whether production of DNase by GAS enhances virulence. To test the hypothesis...
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