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Histone H1 kills MRSA

1 Nov 2024

Abstract excerpt

The antimicrobial activity of histones was discovered in the 1940s, but their mechanism of action is not fully known. Here we show that methicillin-resistant Staphylococcus aureus (MRSA) is susceptible to histone H1 (H1), even in the presence of divalent cations and serum. Through selective evolution and a genome-wide screen of a transposon library, as well as physiological and pharmacological experiments, we...

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Share to Antimicrobial Peptides and Activities
Share to Antimicrobial Resistance in Staphylococcus
Share to Peptidase Inhibition and Analysis

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Identifiers

PMID: 39546397
DOI: 10.1016/j.celrep.2024.114969

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