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Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

13 Feb 2023

Abstract excerpt

Hepatitis E virus (HEV) is an RNA virus responsible for over 20 million infections annually. HEV's open reading frame (ORF)1 polyprotein is essential for genome replication, though it is unknown how the different subdomains function within a structural context. Our data show that ORF1 operates as a multifunctional protein, which is not subject to proteolytic processing. Supporting this model, scanning mutagenesis...

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PMID: 36852909
DOI: 10.7554/elife.80529

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