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Article

Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi.

International journal of biological macromolecules - 1 May 2017

Bittencourt Ize de Aguiar, Serpeloni Mariana, Hiraiwa Priscila Mazzochi, de Arruda Campos Brasil de Souza Tatiana, Ávila Andréa Rodrigues

Abstract excerpt

The RNA helicase DEAD-box protein Sub2 (yeast)/UAP56 (mammals) is conserved across eukaryotes and is essential for mRNA export in trypanosomes. Despite the high conservation of Sub2 in lower eukaryotes such as Trypanosoma cruzi, the low conservation of other mRNA export factors raises questions regarding whether the mode of action of TcSub2 is similar to that of orthologs from other eukaryotes. Mutation of the...

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PMID: 28212935
DOI: 10.1016/j.ijbiomac.2017.02.050

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