Article
HFE gene mutation and iron overload in Egyptian pediatric acute lymphoblastic leukemia survivors: a single-center study.
Hematology (Amsterdam, Netherlands) - 1 Aug 2017
El-Rashedi Farida H, El-Hawy Mahmoud A, El-Hefnawy Sally M, Mohammed Mona M
Abstract excerpt
BACKGROUND: Hereditary hemochromatosis gene (HFE) mutations have a role in iron overload in pediatric acute lymphoblastic leukemia (ALL) survivors. We aimed to evaluate the genotype frequency and allelic distribution of the two HFE gene mutations (C282Y and H63D) in a sample of Egyptian pediatric ALL survivors and to detect the impact of these two mutations on their iron profile. PATIENTS AND METHODS: This study...
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