Article
HFE gene mutations in patients with acute leukemia.
Leukemia & lymphoma - 1 Nov 2006
Viola Assunta, Pagano Leonilde, Laudati Daniela, D'Elia Rossella, D'Amico Maria Rosaria, Ammirabile Massimiliano, Palmieri Salvatore, Prossomariti Luciano, Ferrara Felicetto
Abstract excerpt
An increased incidence of HFE gene mutations has been described in hematologic malignancies. In the present study, we investigated the allelic frequency of HFE gene mutations in 154 adult patients with acute leukemia (AL) [107 acute myeloid leukemia (AML), 20 acute promyelocytic leukemia (APL) and 27 acute lymphoblastic leukemia (ALL)]. The allelic frequency of the H63D mutation was 29% in AL patients and 25% in...
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