Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diagnostic utility of HFE variants in Spanish patients: association with HLA alleles and role in susceptibility to acute lymphoblastic leukemia.

Gene - 1 Feb 2013

Rodríguez-López Raquel, Donoso Marisol, Fernández-Cavada María, González Luz María, Margallo Aranza, Corral César, Gallego Mercedes, García de Cáceres María Teresa, Herrera Trinidad, González Cristina, Vagace José Manuel, Gervasini Guillermo

Abstract excerpt

Two single nucleotide polymorphisms (SNPs) in the Human Hemochromatosis (HFE) gene, C282Y and H63D, are the major variants associated to altered iron status and it is well known that these mutations are in linkage disequilibrium with certain Human Leukocyte Antigen (HLA)-A alleles. In addition, the C282Y SNP has been previously suggested to confer susceptibility to acute lymphoblastic leukemia (ALL). We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemochromatosis
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to HLA-A Antigens

Share to Linkage Disequilibrium

Share to Membrane Proteins

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 23178241
DOI: 10.1016/j.gene.2012.10.090

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diagnostic utility of HFE variants in Spanish patients: association with HLA alleles and role in susceptibility to acute lymphoblastic leukemia.PMID 23178241Read ↗

HFE gene mutation and iron overload in Egyptian pediatric acute lymphoblastic leukemia survivors: a single-center study.Semantic proximity Read ↗

Hemochromatosis gene in leukemia and lymphoma.Semantic proximity Read ↗

HFE gene mutations in susceptibility to childhood leukemia: HuGE review.Semantic proximity Read ↗

An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia.Semantic proximity Read ↗

Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders.Semantic proximity Read ↗

Human leukocyte antigen haplotypes and HFE mutations in Spanish hereditary hemochromatosis and sporadic porphyria cutanea tarda.Semantic proximity Read ↗

Analysis of HLA-A antigens and C282Y and H63D mutations of the HFE gene in Brazilian patients with hemochromatosis.Semantic proximity Read ↗

HFE-codon 63/282 (H63D/C282Y) gene variants in Mexican Mestizos are not risk factors for leukemia.Semantic proximity Read ↗

Analysis of HFE and TFR2 gene mutations in patients with acute leukemia.Semantic proximity Read ↗

HLA haplotypes associated with hemochromatosis mutations in the Spanish population.Semantic proximity Read ↗

Iron loading in HFE p.C282Y homozygotes found by population screening: relationships to HLA-type and T-lymphocyte subsets.Semantic proximity Read ↗

Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.