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Article

Next-generation cDNA screening for oncogene and resistance phenotypes.

PloS one - 1 Jan 2012

Shindoh Nobuaki, Yoda Akinori, Yoda Yuka, Sullivan Timothy J, Weigert Oliver, Lane Andrew A, Kopp Nadja, Bird Liat, Rodig Scott J, Fox Edward A, Weinstock David M

Abstract excerpt

There is a pressing need for methods to define the functional relevance of genetic alterations identified by next-generation sequencing of cancer specimens. We developed new approaches to efficiently construct full-length cDNA libraries from small amounts of total RNA, screen for transforming and resistance phenotypes, and deconvolute by next-generation sequencing. Using this platform, we screened a panel of cDNA...

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Identifiers

PMID: 23145123
DOI: 10.1371/journal.pone.0049201
PMCID: PMC3492311

Genes

ERBB2
KRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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