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Article

The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2016

Maxson Julia E, Luty Samuel B, MacManiman Jason D, Paik Jason C, Gotlib Jason, Greenberg Peter, Bahamadi Swaleh, Savage Samantha L, Abel Melissa L, Eide Christopher A, Loriaux Marc M, Stevens Emily A, Tyner Jeffrey W

Abstract excerpt

PURPOSE: Colony-stimulating factor 3 receptor (CSF3R) mutations have been identified in the majority of chronic neutrophilic leukemia (CNL) and a smaller percentage of atypical chronic myeloid leukemia (aCML) cases. Although CSF3R point mutations (e.g., T618I) are emerging as key players in CNL/aCML, the significance of rarer CSF3R mutations is unknown. In this study, we assess the importance of the CSF3R T640N...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26475333
DOI: 10.1158/1078-0432.CCR-14-3100
PMCID: PMC4738027

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