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Article

Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer.

Oncotarget - 1 Dec 2012

Chan David W, Mak Celia S L, Leung Thomas H Y, Chan Karen K L, Ngan Hextan Y S

Abstract excerpt

Although the mortality rate of endometrial cancer is comparatively low in gynecologic malignancies, a rising trend of this cancer has been observed for the past decade. The understanding of the molecular mechanism will favor for the clinical management of this disease. Aberrant activation of Wnt/β-catenin signaling pathway plays a major role in the pathogenesis of endometrioid adenocarcinoma including this cancer...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23295859
DOI: 10.18632/oncotarget.667
PMCID: PMC3681493

Genes

TCF4
FGF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer.PMID 23295859Read ↗

Loss-of-function mutations of SOX17 lead to YAP/TEAD activation-dependent malignant transformation in endometrial cancer.Semantic proximity Read ↗

Expression of human SOX7 in normal tissues and tumorsSemantic proximity Read ↗

Sox7 Is an Independent Checkpoint for β-Catenin Function in Prostate and Colon Epithelial CellsSemantic proximity Read ↗

SOX9 promotes epithelial‑mesenchymal transition via the Hippo‑YAP signaling pathway in gastric carcinoma cellsSemantic proximity Read ↗

E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA‐383‐5p transcriptionSemantic proximity Read ↗

Cooperation of Sox4 with β-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcomaSemantic proximity Read ↗

SOX21-AS1 augmented cervical cancer growth by triggering FZD3 to activate the Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

Pan-cancer Analysis Reveals Cancer-dependent Expression of SOX17 and Associated Clinical OutcomesSemantic proximity Read ↗

Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in TumorigenesisSemantic proximity Read ↗

Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategiesSemantic proximity Read ↗

SOX transcription factors direct TCF-independent WNT/beta-catenin transcriptionSemantic proximity Read ↗

Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis.Semantic proximity Read ↗

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