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Article

Sox7 Is an Independent Checkpoint for β-Catenin Function in Prostate and Colon Epithelial Cells

1 Sept 2008

Abstract excerpt

The presence of somatic beta-catenin mutations in some prostate cancers implies that aberrant WNT signaling is involved in the cancer development. Although beta-catenin stability is regulated by a multicomponent destruction complex, mutational alterations of beta-catenin or other components of the destruction complexes are rare in prostate tumors. Therefore, beta-catenin may be regulated by another protein in the...

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PMID: 18819930
DOI: 10.1158/1541-7786.mcr-07-2175

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