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Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

14 Dec 2016

Abstract excerpt

The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We investigated HIV-1 ex vivo infection of SCD peripheral blood mononuclear cells (PBMCs) and found that HIV-1 replication was inhibited at the level of reverse...

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PMID: 28203649
DOI: 10.1182/bloodadvances.2016000745

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