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Article

The secondary resistome of multidrug-resistant Klebsiella pneumoniae.

Scientific reports - 15 Feb 2017

Jana Bimal, Cain Amy K, Doerrler William T, Boinett Christine J, Fookes Maria C, Parkhill Julian, Guardabassi Luca

Abstract excerpt

Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due to multidrug resistance. We hypothesized that antimicrobial resistance can be reversed by targeting chromosomal non-essential genes that are not responsible for acquired resistance but essential for resistant bacteria under therapeutic concentrations of antimicrobials. Conditional essentiality of individual genes...

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Identifiers

PMID: 28198411
DOI: 10.1038/srep42483
PMCID: PMC5309761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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