Article
Confounding effects of microbiome on the susceptibility of TNFSF15 to Crohn's disease in the Ryukyu Islands.
Human genetics - 1 Apr 2017
Nakagome Shigeki, Chinen Hiroshi, Iraha Atsushi, Hokama Akira, Takeyama Yasuaki, Sakisaka Shotaro, Matsui Toshiyuki, Kidd Judith R, Kidd Kenneth K, Said Heba S, Suda Wataru, Morita Hidetoshi, Hattori Masahira, Hanihara Tsunehiko, Kimura Ryosuke, Ishida Hajime, Fujita Jiro, Kinjo Fukunori, Mano Shuhei, Oota Hiroki
Abstract excerpt
Crohn's disease (CD) involves chronic inflammation in the gastrointestinal tract due to dysregulation of the host immune response to the gut microbiome. Even though the host-microbiome interactions are likely contributors to the development of CD, a few studies have detected genetic variants that change bacterial compositions and increase CD risk. We focus on one of the well-replicated susceptible genes, tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.