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Genetic Deficiencies of Hyaluronan Degradation

16 Jul 2024

Abstract excerpt

Hyaluronan (HA) is a large polysaccharide that is broadly distributed and highly abundant in the soft connective tissues and embryos of vertebrates. The constitutive turnover of HA is very high, estimated at 5 g per day in an average (70 kg) adult human, but HA turnover must also be tightly regulated in some processes. Six genes encoding homologues to bee venom hyaluronidase (HYAL1, HYAL2, HYAL3, HYAL4,...

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PMID: 39056785
DOI: 10.3390/cells13141203

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