Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.

doi:10.1007/s00125-013-2985-y

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Article

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.

Diabetologia - 1 Oct 2013

van Vliet-Ostaptchouk J V, den Hoed M, Luan J, Zhao J H, Ong K K, van der Most P J, Wong A, Hardy R, Kuh D, van der Klauw M M, Bruinenberg M, Khaw K T, Wolffenbuttel B H R, Wareham N J, Snieder H, Loos R J F

Abstract excerpt

AIMS/HYPOTHESIS: Genetic pleiotropy may contribute to the clustering of obesity and metabolic conditions. We assessed whether genetic variants that are robustly associated with BMI and waist-to-hip ratio (WHR) also influence metabolic and cardiovascular traits, independently of obesity-related traits, in meta-analyses of up to 37,874 individuals from six European population-based studies. METHODS: We examined...

Topics

Alleles
Body Mass Index
Genetic Predisposition to Disease
Humans
Obesity

Source

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Identifiers

PMID: 23827965
DOI: 10.1007/s00125-013-2985-y

Genes

DNAJC27
GRB14
MTCH2
POC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.