Article
Functional mucous layer and healing of proximal colonic anastomoses in an experimental model.
The British journal of surgery - 1 Apr 2017
Bosmans J W A M, Jongen A C H M, Birchenough G M H, Nyström E E L, Gijbels M J J, Derikx J P M, Bouvy N D, Hansson G C
Abstract excerpt
BACKGROUND: Anastomotic leakage (AL) is the most dreaded complication after colorectal surgery, causing high morbidity and mortality. Mucus is a first line of defence against external factors in the gastrointestinal tract. In this study, the structural mucus protein Muc2 was depleted in genetically engineered mice and the effect on healing of colonic anastomoses studied in an experimental model. METHODS: Mice of...
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