Article
Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice.
The Journal of biological chemistry - 13 Nov 2020
Schroeder Bjoern O, Birchenough George M H, Pradhan Meenakshi, Nyström Elisabeth E L, Henricsson Marcus, Hansson Gunnar C, Bäckhed Fredrik
Abstract excerpt
The intestinal mucus layer is a physical barrier separating the tremendous number of gut bacteria from the host epithelium. Defects in the mucus layer have been linked to metabolic diseases, but previous studies predominantly investigated mucus function during high-caloric/low-fiber dietary interventions, thus making it difficult to separate effects mediated directly through diet quality from potential...
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