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Article

ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2010

Nighot Prashant K, Blikslager Anthony T

Abstract excerpt

We have previously shown an important role of the chloride channel ClC-2 in orchestrating repair of tight junctions in ischemia-injured mucosa. In this study, we examined the role of ClC-2 in regulating barrier function of normal murine intestinal mucosa. Ex vivo, ClC-2-/- ileal mucosa mounted in...

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Source

Identifiers

PMID: 20489043
DOI: 10.1152/ajpgi.00520.2009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20489043-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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