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Article

Vulnerability of primitive human placental trophoblast to Zika virus

13 Feb 2017

Abstract excerpt

Significance We have tested the hypothesis that the placenta of early pregnancy might be more easily breached by the Zika virus (ZIKV) than the relatively resistant outer cells of the mature placenta. Colonies of placental lineage cells derived from embryonic stem cells, which are probably analogous to the primitive placenta at implantation, were lysed more rapidly by an African strain of ZIKV, considered...

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PMID: 28193876
DOI: 10.1073/pnas.1616097114

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