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Article

HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells

10 Sept 2016

Abstract excerpt

PROBLEM: Zika virus (ZIKV) has gained public concern for its association with microcephaly in infants born to ZIKV-infected mothers. To reach the fetus the virus must overcome the defense mechanisms provided by trophoblast cells. Additionally, in the first trimester, the integrity of the placenta is critical for fetal protection as damage to differentiating trophoblast can affect placental formation and function....

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PMID: 27613665
DOI: 10.1111/aji.12578

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