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African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast

9 Jul 2018

Abstract excerpt

Zika virus (ZIKV) drew worldwide attention when a recent epidemic was linked to fetal microcephaly. Here we used human embryonic stem cell derived trophoblasts as a model for primitive placental trophoblast to test the hypothesis that there are differences in how the two genetically distinct ZIKV lineages, African (AF) and Asian (AS), target the human placenta. Upon infection with three AF (ib-H30656,...

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PMID: 29985932
DOI: 10.1371/journal.pone.0200086

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