Article
5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults.
Cell biochemistry and function - 1 Jan 2014
Zappacosta Bruno, Graziano Mirella, Persichilli Silvia, Di Castelnuovo Augusto, Mastroiacovo Pierpaolo, Iacoviello Licia
Abstract excerpt
Two genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) can influence the plasma homocysteine (Hcy) levels, especially in the presence of an inadequate folate status. The aim of this study was to evaluate the frequencies of C677T and of A1298C MTHFR polymo...
Topics
- Adult
- Female
- Folic Acid
- Gene Frequency
- Genotype
- Homocysteine
- Humans
- Italy
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Polymorphism, Single Nucleotide