Article
Two stable variants of Burkholderia pseudomallei strain MSHR5848 express broadly divergent in vitro phenotypes associated with their virulence differences.
PloS one - 1 Jan 2017
Shea A A, Bernhards R C, Cote C K, Chase C J, Koehler J W, Klimko C P, Ladner J T, Rozak D A, Wolcott M J, Fetterer D P, Kern S J, Koroleva G I, Lovett S P, Palacios G F, Toothman R G, Bozue J A, Worsham P L, Welkos S L
Abstract excerpt
Burkholderia pseudomallei (Bp), the agent of melioidosis, causes disease ranging from acute and rapidly fatal to protracted and chronic. Bp is highly infectious by aerosol, can cause severe disease with nonspecific symptoms, and is naturally resistant to multiple antibiotics. However, no vaccine exists. Unlike many Bp strains, which exhibit random variability in traits such as colony morphology, Bp strain...
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