Article
Genomic comparison and phenotypic profiling of small colony variants of Burkholderia pseudomallei.
PloS one - 1 Jan 2021
Zulkefli Noorfatin Jihan, Teh Cindy Shuan Ju, Mariappan Vanitha, Ngoi Soo Tein, Vadivelu Jamuna, Ponnampalavanar Sasheela, Chai Lay Ching, Chong Chun Wie, Yap Ivan Kok Seng, Vellasamy Kumutha Malar
Abstract excerpt
Burkholderia pseudomallei (B. pseudomallei) is an intracellular pathogen that causes melioidosis, a life-threatening infection in humans. The bacterium is able to form small colony variants (SCVs) as part of the adaptive features in response to environmental stress. In this study, we characterize the genomic characteristics, antimicrobial resistance (AMR), and metabolic phenotypes of B. pseudomallei SCV and wild...
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