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Article

Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex

9 Feb 2017

Abstract excerpt

Disruption of myelination during development has been implicated in a range of neurodevelopmental disorders including tuberous sclerosis complex (TSC). TSC patients with autism display impairments in white matter integrity. Similarly, mice lacking neuronal Tsc1 have a hypomyelination phenotype. However, the mechanisms that underlie these phenotypes remain unknown. In this study, we demonstrate that neuronal...

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PMID: 28183733
DOI: 10.1084/jem.20160446

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